In the 17th century Città di Castello was safe inside its town walls and there weren’t any major developments; apart from a few baroque additions that show the influence of the counter-reform.
The town was now on the border and trade suffered from high tolls as well as very rough roads.
The plague struck again in 1631 and many died.
Suor Veronica Giuliani was one of the most important figures in those years.
Marked with stigmata, she lived ascetically and was proclaimed as a saint during her lifetime.
The confraternities of craftsmen were not able to build a valid economic base to society but the cultural void was partially filled by the Academies that arose. The most important was the Accademia degli Illuminati, founded in 1666. It was the fourth of its kind in Italy.